Clefts, grooves, and (small) pockets: The structure of the retinoblastoma tumor suppressor in complex with its cellular target E2F unveiled.

Comments on findings about the crystal structure of retinoblastoma susceptibility gene product, pRb derived from the E2F transcription factor. Understanding of how pRb inhibit cell growth; Role of the gene in the development of retinoblastoma; Inhibition of cellular DNA synthesis.