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Mesenchymal stromal cells: main factor or helper in regenerative medicine?
- Source :
-
Kidney International Supplements . Sep2011, Vol. 1 Issue 3, p74-76. 3p. - Publication Year :
- 2011
-
Abstract
- Mesenchymal stromal cells (mSCs) are presently studied for the prophylaxis and therapy of a variety of diseases such as acute graft-versus-host disease after allogeneic stem cell transplantation, cardiac indications, bone degeneration, Crohn's disease, and organ rejection, as well as prevention of acute renal failure in high-risk situations. mSCs appear to function through paracrine mechanisms that exert immunosuppressive, anti-inflammatory, anti-apoptotic, mitogenic, and other organ-protective and repair-stimulating actions. mSCs are either cultured in the presence of fetal calf serum (FCS) or platelet lysate (PL). PL lysate-generated mSCs exhibit faster doubling times, different gene expression profiles, and more potent immunosuppressive activity compared with FSC-generated mSCs. The utility of mSCs in the treatment of chronic inflammatory diseases is being evaluated in prospective studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 21571724
- Volume :
- 1
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Kidney International Supplements
- Publication Type :
- Academic Journal
- Accession number :
- 93470761
- Full Text :
- https://doi.org/10.1038/kisup.2011.17