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Immunomodulatory effect of poly-γ-glutamic acid derived from Bacillus subtilis on natural killer dendritic cells.
- Source :
-
Biochemical & Biophysical Research Communications . Jan2014, Vol. 443 Issue 2, p413-421. 9p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Bacillus subtilis-derived γPGA stimulates NKDCs in vitro and in vivo. [•] γPGA stimulation up-regulates MHC class II & co-stimulatory molecules on NKDCs. [•] γPGA stimulates NKDCs to produce pro-inflammatory cytokines such as IFNγ and TNFα. [•] γPGA-activated NKDCs show enhanced cytotoxicity against tumor cells. [•] Thus, NKDCs are one of the key players in anti-tumor immunity induced by γPGA. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 443
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 93655223
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.11.097