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Nickel-Catalyzed Cross-Electrophile Coupling of 2-Chloropyridines with Alkyl Bromides.
- Source :
-
Synlett . 2014, Vol. 25 Issue 2, p233-238. 6p. - Publication Year :
- 2014
-
Abstract
- The synthesis of 2-alkylated pyridines by the nickel-catalyzed cross-coupling of two electrophiles, a 2-chloropyridine and an alkyl bromide, is described. Compared with our previously published conditions for aryl halides, this method uses a different, more rigid, bathophenanthroline ligand and is conducted at high concentration in N,N-dimethylformamide as solvent. The method displays promising functional group compatibility and the conditions are orthogonal to those for the Stille coupling. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ELECTROPHILES
*ALKYLATION
*PYRIDINE synthesis
*ALKYL bromides
*DIMETHYLFORMAMIDE
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 25
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 93682944
- Full Text :
- https://doi.org/10.1055/s-0033-1340151