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Effect of a Preoperative Gabapentin on Postoperative Analgesia in Patients with Inflammatory Bowel Disease Following Major Bowel Surgery: A Randomized, Placebo-Controlled Trial.
- Source :
-
Pain Practice . Feb2014, Vol. 14 Issue 2, p132-139. 8p. 1 Diagram, 2 Charts, 1 Graph. - Publication Year :
- 2014
-
Abstract
- Background Postoperative pain management for patients with inflammatory bowel disease ( IBD) can be challenging. These patients have a high tolerance to pain medication, and relative contraindications to the use of epidural analgesia, limiting the pain management options. We evaluated the effect of a single preoperative gabapentin dose on opioid consumption for patients with IBD undergoing abdominal surgery. Secondary outcomes were postoperative pain scores, opioid-related side effects, and patient's length of hospital stay. Methods Following Research Ethics Board approval and informed written consent, patients were randomly allocated into 2 groups receiving either 600 mg of oral gabapentin or placebo 1 hour before the surgery. A blinded anesthesiologist recorded pain scores at rest and movement twice daily for 2 postoperative days. Also recorded were opioid consumption, time of return of bowel function, time to discharge, and opioid-related side effects on the opioid-related symptom distress scale ( ORSDS). Results Seventy-two patients completed the study. The difference in opioid consumption ( P = 0.4169) and pain scores measured at rest and movement on all 4 postoperative visits was not statistically significant. There was no significant difference between gabapentin and placebo on all the 11 symptoms reported on the ORSDS. There was a slight increase in length of hospital stay in the placebo group, but the return of bowel function was similar between the groups. Conclusions This study examined the effect of a single preoperative administration of gabapentin in patients with IBD undergoing major bowel surgery. Our results suggest a single preoperative oral dose of gabapentin 600 mg does not reduce postoperative pain scores, opioid consumption, or opioid-related side effects. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GABAPENTIN
*CHI-squared test
*FISHER exact test
*INFLAMMATORY bowel diseases
*HEALTH outcome assessment
*POSTOPERATIVE pain
*PREOPERATIVE care
*STATISTICS
*T-test (Statistics)
*U-statistics
*DATA analysis
*RANDOMIZED controlled trials
*VISUAL analog scale
*TREATMENT effectiveness
*BLIND experiment
*DATA analysis software
*DESCRIPTIVE statistics
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 15307085
- Volume :
- 14
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Pain Practice
- Publication Type :
- Academic Journal
- Accession number :
- 94007169
- Full Text :
- https://doi.org/10.1111/papr.12058