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A subset of CD4+ thymocytes selected by MHC Class I molecules.

Authors :
Bendelac, Albert
Killeen, Nigel
Source :
Science. 3/25/1994, Vol. 263 Issue 5154, p1774. 5p. 2 Charts, 21 Graphs.
Publication Year :
1994

Abstract

Reports on the presence of a subset of thymocytes in normal mice that expresses CD4 but uses class I for positive selection. Thymic selection requirements; Nature of its lineage commitment; CD4 and CD8's lack of contribution of signals that direct their maturation into the CD4+ and CD-8- lineages.

Subjects

Subjects :
*MICE
*GENETICS

Details

Language :
English
ISSN :
00368075
Volume :
263
Issue :
5154
Database :
Academic Search Index
Journal :
Science
Publication Type :
Academic Journal
Accession number :
9405241300
Full Text :
https://doi.org/10.1126/science.7907820