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Expression of α-taxilin in the murine gastrointestinal tract: potential implication in cell proliferation.
- Source :
-
Histochemistry & Cell Biology . Feb2014, Vol. 141 Issue 2, p165-180. 16p. 8 Color Photographs. - Publication Year :
- 2014
-
Abstract
- α-Taxilin, a binding partner of the syntaxin family, is a candidate tumor marker. To gain insight into the physiological role of α-taxilin in normal tissues, we examined α-taxilin expression by Western blot and performed immunochemical analysis in the murine gastrointestinal tract where cell renewal vigorously occurs. α-Taxilin was expressed in the majority of the gastrointestinal tract and was prominently expressed in epithelial cells positive for Ki-67, a marker of actively proliferating cells. In the small intestine, α-taxilin was expressed in transient-amplifying cells and crypt base columnar cells intercalated among Paneth cells. In the corpus and antrum of the stomach, α-taxilin was expressed in cells localized in the lower pit and at the gland, respectively, but not in parietal or zymogenic cells. During development of the small intestine, α-taxilin was expressed in Ki-67-positive regions. Inhibition of cell proliferation by suppression of the Notch cascade using a γ-secretase inhibitor led to a decrease in α-taxilin- and Ki-67-positive cells in the stomach. These results suggest that expression of α-taxilin is regulated in parallel with cell proliferation in the murine gastrointestinal tract. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09486143
- Volume :
- 141
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Histochemistry & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 94062271
- Full Text :
- https://doi.org/10.1007/s00418-013-1147-0