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Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia.
- Source :
-
Progress in Neuro-Psychopharmacology & Biological Psychiatry . Apr2014, Vol. 50, p110-115. 6p. - Publication Year :
- 2014
-
Abstract
- Abstract: Neuropsychological endophenotype approach is an emerging strategy in schizophrenia research to understand and identify the functional importance of genetically transmitted, brain-based deficits present in this disorder. Accumulating evidence indicated that working memory deficit is a core neuropsychological dysfunction in schizophrenia and a primary endophenotype indexing the liability to develop schizophrenia. Genetic variation in ankyrin 3 gene (ANK3) is likely to have widespread cognitive effects. Our previous study has identified a significant association of ANK3 SNPs and schizophrenia. In this study, we aimed to examine whether the schizophrenia-risk SNPs within ANK3 may affect working memory deficits in schizophrenia patients. Herein, we assess the working memory performance in 163 patients with first-episode, antipsychotic-naïve schizophrenia and 42 sex, age-matched healthy subjects using N-back task. Two SNPs rs10761482 and rs10994336 were genotyped among the patients and 209 controls. Our results showed that schizophrenia patients showed significantly poorer performance than healthy controls on N-back task (ps<0.01). After adjusting for the scores of intelligence quotient, memory quotient and the demographic factors, there was a significant genotype effect of the rs10994336 on the accuracy rate and reaction time of 2-back item (p =0.048 and 0.024, respectively). Post-hoc analyses showed that patients with rs10994336T/T genotype had significantly lower accuracy rate and more reaction time at 2-back task than those with T/C and C/C genotypes. The association of SNP rs10994336 with schizophrenia was replicated in our sample (genotypic p =0.024 and allelic p =0.006). However, we did not find any significant association of rs10761482 with schizophrenia and parameters in N-back task. Our results indicated that genetic variation within ANK3 may exert gene-specific modulating effects on working memory deficits in schizophrenia. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 02785846
- Volume :
- 50
- Database :
- Academic Search Index
- Journal :
- Progress in Neuro-Psychopharmacology & Biological Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 94309626
- Full Text :
- https://doi.org/10.1016/j.pnpbp.2013.12.010