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Suppression of protein kinase C-ζ attenuates vascular leakage via prevention of tight junction protein decrease in diabetic retinopathy.

Authors :
Song, Hyun Beom
Jun, Hyoung-Oh
Kim, Jin Hyoung
Yu, Young Suk
Kim, Kyu Won
Kim, Jeong Hun
Source :
Biochemical & Biophysical Research Communications. Jan2014, Vol. 444 Issue 1, p63-68. 6p.
Publication Year :
2014

Abstract

Highlights: [•] Suppression of PKC ζ effectively attenuated vascular leakage in diabetic retina. [•] Inhibition of PKC ζ prevented tight junction protein decrease on retinal vessels. [•] PKC ζ inhibition prevented tight junction loss in HRMECs under diabetic condition. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0006291X
Volume :
444
Issue :
1
Database :
Academic Search Index
Journal :
Biochemical & Biophysical Research Communications
Publication Type :
Academic Journal
Accession number :
94365486
Full Text :
https://doi.org/10.1016/j.bbrc.2014.01.002