Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)15 motif.

Highlights: [•] Direct interactions of prohibitin (PHB) and/or prohibiton (PHB2) with the (TGYCC)15 motif was indicated in this study. [•] PHB and PHB2 associated with the (TGYCC)15 motif in vivo regardless of the p53 status and apoptotic stress. [•] PHB and PHB2 contribute to PIG3-mediated apoptosis by binding to the PIG3 promoter (TGYCC)15 motif. [Copyright &y& Elsevier]