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Inhibition of Notch signaling leads to increased intracellular ROS by up-regulating Nox4 expression in primary HUVECs.
- Source :
-
Cellular Immunology . Feb2014, Vol. 287 Issue 2, p129-135. 7p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Blockade of Notch signaling increased reactive oxygen species (ROS) in primary HUVECs. [•] Abruption of ROS generation abolished Notch blockade-induced HUVEC proliferation, migration and adhesion. [•] The enhanced generation of ROS after blocking Notch signal was accompanied by augmented expression of Nox4. [•] Increased expression of Nox4 led to enhanced phosphorylation of VEGFR2 and ERK in HUVECs. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00088749
- Volume :
- 287
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cellular Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 94365587
- Full Text :
- https://doi.org/10.1016/j.cellimm.2013.12.009