The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model.

Highlights: [•] This review focuses on the behavioral and histopathological signature of AD in SAMP8 mice. [•] The behavioral and pathological features detected by the different methods in SAMP8 mice at different ages were listed. [•] The preclinical trials of potential therapeutic modalities using SAMP8 mice were summarized. [•] We compared the merits and limitations of SAMP8 mice with the transgenic mouse as AD animal model. [ABSTRACT FROM AUTHOR]