Induction of apoptosis by isoegomaketone from Perilla frutescens L. in B16 melanoma cells is mediated through ROS generation and mitochondrial-dependent, -independent pathway.

Highlights: [•] IK from P. frutescens L. inhibited cell viability in a dose-dependent manner. [•] IK-mediated ROS generation is involved in apoptotic cell death in B16 cells. [•] IK induces apoptosis via mitochondrial-dependent, -independent pathway in B16 cells. [ABSTRACT FROM AUTHOR]