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H3K9 histone methyltransferase G9a-mediated transcriptional activation of p21.
- Source :
-
FEBS Letters . Mar2014, Vol. 588 Issue 5, p685-691. 7p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] G9a upregulates p21 expression independently of its HMTase activity. [•] Positive regulation of p21 by G9a is p53 independent. [•] G9a interacts with PCAF to activate p21 expression. [•] G9a and PCAF are recruited to p21 promoter upon etoposide treatment. [•] G9a inhibits cell survival via p21-mediated apoptosis upon cellular stress. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 588
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 94569768
- Full Text :
- https://doi.org/10.1016/j.febslet.2014.01.039