Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy.

Highlights: [•] Enhanced miR-21 is associated with podocyte and tubular cell injuries in IgA nephropathy. [•] Inhibition of miR-21 prevents fibrogenic activation in podocytes and tubular cells. [•] Inhibition of miR-21 prevents PTEN/Akt pathway activation in podocytes and tubular cells. [ABSTRACT FROM AUTHOR]