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Yin Yang 1 regulates the transcriptional repression of survivin.

Authors :
Galloway, Nicholas R.
Diaz Osterman, Carlos J.
Reiber, Karl
Jutzy, Jessica M.S.
Li, Fengzhi
Sui, Guangchao
Soto, Ubaldo
Wall, Nathan R.
Source :
Biochemical & Biophysical Research Communications. Feb2014, Vol. 445 Issue 1, p208-213. 6p.
Publication Year :
2014

Abstract

Highlights: [•] YY1 overexpression resulted in survivin promoter repression in a luciferase system. [•] YY1 knockdown using siRNA releases the survivin repression. [•] Using a YY1 tet-off system, YY1 expression represses survivin expression. [•] YY1 is capable of directly binding to the survivin promoter. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0006291X
Volume :
445
Issue :
1
Database :
Academic Search Index
Journal :
Biochemical & Biophysical Research Communications
Publication Type :
Academic Journal
Accession number :
94640042
Full Text :
https://doi.org/10.1016/j.bbrc.2014.01.169