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Foxp3+ Regulatory T Cells in Mouse Models of Type 1 Diabetes.
- Source :
-
Journal of Diabetes Research . 2013, p1-10. 10p. - Publication Year :
- 2013
-
Abstract
- Studies on human type 1 diabetes (T1D) are facilitated by the availability of animal models such as nonobese diabetic (NOD) mice that spontaneously develop autoimmune diabetes, as well as a variety of genetically engineered mouse models with reduced genetic and pathogenic complexity, as compared to the spontaneous NOD model. In recent years, increasing evidence has implicated CD4+CD25+ regulatory T (Treg) cells expressing the transcription factor Foxp3 in both the breakdown of self-tolerance and the restoration of immune homeostasis in T1D. In this paper, we provide an overview of currently available mouse models to study the role of Foxp3+ Treg cells in the control of destructive β cell autoimmunity, including a novel NOD model that allows specific and temporally controlled deletion of Foxp3+ Treg cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23146745
- Database :
- Academic Search Index
- Journal :
- Journal of Diabetes Research
- Publication Type :
- Academic Journal
- Accession number :
- 94677607
- Full Text :
- https://doi.org/10.1155/2013/940710