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Long-term curcumin treatment antagonizes masseter muscle alterations induced by chronic unpredictable mild stress in rats.
- Source :
-
Archives of Oral Biology . Mar2014, Vol. 59 Issue 3, p258-267. 10p. - Publication Year :
- 2014
-
Abstract
- Abstract: Objective: To investigate the correlation between psychological stress and masseter muscle (MM) alterations, and explore the therapeutic agents for restoring the impaired masticatory muscle. Design: We established a chronic unpredictable mild stress (CUMS) animal model and observed the changes of ultrastructure, redox homeostasis and energy metabolism in MM in rats with and without curcumin treatment. Results: The depressive-like behavior in stressed rats was confirmed by the evidences of altered behaviors in sucrose preference test and open field test; while these phenomena were eased by curcumin. Except for the pathological changes in ultrastructure, decreased SOD, GSH-Px, CAT, Na+-K+ATPase, and Ca2+-Mg2+ATPase activities as well as increased MDA and LD content and LDH activity were also observed in MM in stressed rats. However, curcumin was capable of reversing CUMS-induced MM disorder by improving the activities of the examined anti-oxidant enzymes and energy metabolism enzymes. Additionally, the increased MDA content, LD content, and LDH activity in stressed rats were reduced by curcumin. Conclusion: All the findings indicate the adverse effects of CUMS on MM function in rats, and raise the possibility of developing curcumin as a potential therapeutic agent for psychological stress-induced masseter dysfunction. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00039969
- Volume :
- 59
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Archives of Oral Biology
- Publication Type :
- Academic Journal
- Accession number :
- 94688427
- Full Text :
- https://doi.org/10.1016/j.archoralbio.2013.12.001