Salmonella vaccines: lessons from the mouse model or bad teaching?

Highlights: [•] Invasive non-typhoidal salmonelloses (iNTS) are increasing. [•] Vaccines for iNTS will likely be different from those developed for typhoid fever. [•] Typhoid vaccines target antibodies against Vi antigen, or use an orally administered, live vaccine. [•] It is not clear whether the immune correlates of protection seen in mouse typhoid models will be useful in developing new iNTS vaccines. [•] Recent iterations of these models, with ‘humanisation’, may assist in identifying functional correlates of protection. [ABSTRACT FROM AUTHOR]