The link between genetic variation and variability in vaccine responses: Systematic review and meta-analyses.

Highlights: [•] Our systematic review shows that several genetic variations were significantly associated with responsiveness to vaccines. [•] As most of the included studies investigated different polymorphisms, meta-analyses could be performed only for seven polymorphisms. [•] Future studies are required to further clarify the link between genetic variations and variability in immune responses to vaccines. [ABSTRACT FROM AUTHOR]