Back to Search
Start Over
Aberrant cytokeratin expression and high susceptibility to apoptosis in autoimmune hepatitis
- Source :
-
Hepatology Research . Mar2003, Vol. 25 Issue 3, p271. 10p. - Publication Year :
- 2003
-
Abstract
- Immunopathological differences between autoimmune hepatitis (AIH) and chronic hepatitis C (CH-C) have not been well investigated. Therefore, we immunohistochemically examined the expression of various cytokeratins (CKs) not only in liver tissues of AIH but also in those of CH-C at the active stage. Furthermore, to evaluate the immune surveillance system and the susceptibility to apoptosis, immunohistochemical staining of human leukocyte antigen (HLA)-DRα, cathepsin D, B cell leukemia-2 (bcl-2), bcl-2-associated X protein (bax) and caspase 3 was also performed. Heterogeneous expression of CK 8 and CK 18 was observed in hepatocytes of AIH, while homogeneous expression was observed in hepatocytes of CH-C. Aberrant expression of CK 7 and CK 19 was observed in hepatocytes of AIH, while it was not in hepatocytes of CH-C. Expression of HLA-DRα was observed in hepatocytes of AIH but not in those of CH-C. Furthermore, expression of cathepsin D, bax and caspase 3 was much stronger in hepatocytes of AIH than in those of CH-C. These results indicate that cytoskeletal alterations of hepatocytes in AIH may increase the susceptibility to apoptosis and induce hepatocyte destruction. [Copyright &y& Elsevier]
- Subjects :
- *CHRONIC active hepatitis
*HEPATITIS C
*IMMUNOHISTOCHEMISTRY
*APOPTOSIS
*LEUKEMIA
Subjects
Details
- Language :
- English
- ISSN :
- 13866346
- Volume :
- 25
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Hepatology Research
- Publication Type :
- Academic Journal
- Accession number :
- 9500125
- Full Text :
- https://doi.org/10.1016/S1386-6346(02)00277-2