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Use of fingolimod in patients with relapsing remitting multiple sclerosis in Kuwait.
- Source :
-
Clinical Neurology & Neurosurgery . 2014, Vol. 119, p17-20. 4p. - Publication Year :
- 2014
-
Abstract
- Background: Post-marketing studies are important to confirm what was established in clinical trials, and to assess the intermediate and long-term efficacy and safety. Objective: To assess efficacy and safety of fingolimod in multiple sclerosis (MS) in Kuwait. Methods: We retrospectively evaluated MS patients using the MS registries in 3 MS clinics. Relapsing remitting MS patients according to revised 2010 McDonald criteria who had been treated with fingolimod for at least 12 months were included. Primary endpoint was proportion of relapse-free patients at last follow-up. Secondary endpoints were mean change in EDSS and proportion of patients with MRI activity (gadolinium-enhancing or new/enlarging T2 lesions). Results: 76 patients met the inclusion criteria. Mean age and mean disease duration were 34.43 and 7.82 years respectively. Mean duration of exposure to fingolimod was 18.50 months. Proportion of relapse-free patients was 77.6% at last follow-up. Mean EDSS score significantly improved (2.93 versus 1.95; p < 0.0001) while 17.1% of patients continued to have MRI activity versus 77.6% at baseline (p<0.0001). Four patients stopped fingolimod due to disease breakthrough (n = 3) and lymphadenitis (n = 1). Conclusion: Fingolimod is safe and effective in reducing clinical and radiological disease activity in relapsing remitting MS patients. Our results are comparable to reported results of phase III studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03038467
- Volume :
- 119
- Database :
- Academic Search Index
- Journal :
- Clinical Neurology & Neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- 95002146
- Full Text :
- https://doi.org/10.1016/j.clineuro.2014.01.007