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Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1β.

Authors :
Munari, Francesca
Gajda, Michal Jan
Hiragami-Hamada, Kyoko
Fischle, Wolfgang
Zweckstetter, Markus
Source :
FEBS Letters. Apr2014, Vol. 588 Issue 7, p1094-1099. 6p.
Publication Year :
2014

Abstract

Highlights: [•] HP1β contains two primary sites for CK2 with distinct phosphorylation kinetics. [•] Localized conformational and dynamic changes occur at the sites of phosphorylation. [•] HP1β phosphorylated at S89 and S175 retains its ability to bind chromatin. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00145793
Volume :
588
Issue :
7
Database :
Academic Search Index
Journal :
FEBS Letters
Publication Type :
Academic Journal
Accession number :
95016530
Full Text :
https://doi.org/10.1016/j.febslet.2014.02.019