Interaction between the retinoblastoma protein and the oncoprotein MDM2.

Demonstrates that the MDM2 oncoprotein interacts physically and functionally with pRB and inhibits pRB growth regulatory function. Deregulated cell proliferation due to inactivation of tumor-suppressor genes; Mutation of p53 and retinoblastoma genes in human cancers; Inactivation of RB and p53 in a variety of naturally occurring human tumors; Actions of different DNA tumor virus groups.