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Interleukin-6-deficient mice develop mature-onset obesity.
- Source :
-
Nature Medicine . Jan2002, Vol. 8 Issue 1, p75. 5p. - Publication Year :
- 2002
-
Abstract
- The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6-/- mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement. The obese Il6-/- mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment. To investigate the possible mechanism and site of action of the anti-obesity effect of IL-6, we injected rats centrally and peripherally with IL-6 at low doses. Intracerebroventricular, but not intraperitoneal IL-6 treatment increased energy expenditure. In conclusion, centrally acting IL-6 exerts anti-obesity effects in rodents. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERLEUKIN-6
*CYTOKINES
*MICE
*BIOCHEMISTRY
Subjects
Details
- Language :
- English
- ISSN :
- 10788956
- Volume :
- 8
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Nature Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 9511292
- Full Text :
- https://doi.org/10.1038/nm0102-75