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Identification of novel bivalent mimetics of annonaceous acetogenins via a scaffold-hopping strategy.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Apr2014, Vol. 24 Issue 7, p1650-1653. 4p. - Publication Year :
- 2014
-
Abstract
- Abstract: A series of novel bivalent mimetics of annonaceous acetogenins have been designed, synthesized, and evaluated. Among these, compound 7 bearing a homopiperazine ring in the middle region exhibited more potent growth inhibitory activity and higher selectivity against cancer cells over normal cells by comparison with AA005. This work indicates that modification of the middle piperazine ring is a useful optimizing tool for the simplified acetogenin mimetics. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 24
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 95125952
- Full Text :
- https://doi.org/10.1016/j.bmcl.2014.02.072