Synthetic Studies Directed toward Kaitocephalin: A Highly Stereocontrolled Route to the Right-Hand Pyrrolidine Core.

A highly stereocontrolled method for the construction of the right-hand segment of kaitocephalin, an antagonist of AMPA/KA and NMDA glutamate receptors, has been developed employing palladium-catalyzed cyclization of an oxiranylacrylate at the quaternary center as the key step. [ABSTRACT FROM AUTHOR]