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Synthesis of Ether-Linkage-Based Cyclic Glycerophospholipid Carrying Methylene Moiety that Improves Membrane Fluidity.

Authors :
Ono, Yutaka
Namekata, Masato
Goto, Rie
Nakamura, Makoto
Shibakami, Motonari
Source :
Synlett. 2009, Issue 5, p759-762. 4p.
Publication Year :
2009

Abstract

A cyclic glycerophospholipid, in which two glycerols are connected via alkyl chains to form a 64-membered macrocycle, was synthesized. The structural features that differentiate this from our analogous lipids previously reported are two methylene moieties in the alkyl chains, which were incorporated to improve membrane fluidity. Fluorescence recovery after photobleaching revealed that the membranes made from the methylene-containing cyclic lipid demonstrated fluidity at room temperature unlike those of a linear alkyl-chain lipid of equal ring size. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09365214
Issue :
5
Database :
Academic Search Index
Journal :
Synlett
Publication Type :
Academic Journal
Accession number :
95202278
Full Text :
https://doi.org/10.1055/s-0028-1087935