Involvement of protein isoprenylation in neuropathic pain induced by sciatic nerve injury in mice.

Highlights: [•] Partial sciatic nerve injury elicited neuropathic pain. [•] Phosphorylation of spinal MARCKS was increased in nerve ligation. [•] Neuropathic pain was attenuated by geranylgeranyl transferase inhibitor. [•] MARCKS protein phosphoryation was mediated by protein isoprelylation. [•] Inhibition of protein isoprenylation could relive neuropathic pain. [Copyright &y& Elsevier]