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The role of an inwardly rectifying K+ channel (Kir4.1) in the inner ear and hearing loss.
- Source :
-
Neuroscience . Apr2014, Vol. 265, p137-146. 10p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Kir4.1 (KCNJ10) is required for EP and spiral ganglion function in the inner ear. [•] Deficiency of Kir4.1 causes deafness with EAST or SeSAME syndromes. [•] Deafness mutants show “loss of function” and can be rescued by WT isoform. [•] Deafness mechanisms of Kir4.1 deficiency are discussed and prospected. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03064522
- Volume :
- 265
- Database :
- Academic Search Index
- Journal :
- Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 95226280
- Full Text :
- https://doi.org/10.1016/j.neuroscience.2014.01.036