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Three-dimensional flow contrast imaging of deep tissue using noncontact diffuse correlation tomography.
- Source :
-
Applied Physics Letters . 3/24/2014, Vol. 104 Issue 12, p1-4. 4p. 1 Diagram, 1 Graph. - Publication Year :
- 2014
-
Abstract
- This study extended our recently developed noncontact diffuse correlation spectroscopy flowmetry system into noncontact diffuse correlation tomography (ncDCT) for three-dimensional (3-D) flow imaging of deep tissue. A linear array of 15 photodetectors and two laser sources connected to a mobile lens-focusing system enabled automatic and noncontact scanning of flow in a region of interest. These boundary measurements were combined with a finite element framework for DCT image reconstruction implemented into an existing software package. This technique was tested in computer simulations and using a tissue-like phantom with anomaly flow contrast design. The cylindrical tube-shaped anomaly was clearly reconstructed in both simulation and phantom. Recovered and assigned flow contrast changes in anomaly were found to be highly correlated: regression slope=1.00, R²=1.00, and p<10-5 in simulation and regression slope≥0.97, R²≥0.96, and p<10-3 in phantom. These results exhibit promise of our ncDCT technique for 3-D imaging of deep tissue blood flow heterogeneities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00036951
- Volume :
- 104
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Applied Physics Letters
- Publication Type :
- Academic Journal
- Accession number :
- 95302336
- Full Text :
- https://doi.org/10.1063/1.4869469