The aging kidney revisited: A systematic review.

Highlights: [•] Progress in genetics and proteomics has provided new insights on renal aging. [•] Renal aging is a multifactorial process involving several key factors. [•] None of the macroscopic and microscopic features of the aging kidney is pathognomonic of aging. [•] The assessment of renal function in the elderly is problematic and it is still debated whether renal aging should be considered as a physiological or pathological process. [•] Proper lifestyle modifications currently represent the most plausible approach to maintain kidney health. [ABSTRACT FROM AUTHOR]