Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites.

Authors :: Brochet, Mathieu
Collins, Mark O.
Smith, Terry K.
Thompson, Eloise
Sebastian, Sarah
Volkmann, Katrin
Schwach, Frank
Chappell, Lia
Gomes, Ana Rita
Berriman, Matthew
Rayner, Julian C.
Baker, David A.
Choudhary, Jyoti
Billker, Oliver
Source :: PLoS Biology. Mar2014, Vol. 12 Issue 3, p1-15. 15p. 2 Diagrams, 5 Graphs.
Publication Year :: 2014
Abstract: : Chemical genetics and a global comparative analysis of phosphorylation and phospholipids in vivo shows that PKG is the upstream regulator that induces calcium signals that enables Plasmodium to progress through its complex life cycle. [ABSTRACT FROM AUTHOR]

Subjects :: *PHOSPHOINOSITIDES
*CGMP-dependent protein kinase
*PLASMODIUM
*PARASITE life cycles
*BIOCHEMICAL genetics
*PHOSPHORYLATION
*PHOSPHOLIPIDS

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