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How introns influence and enhance eukaryotic gene expression
- Source :
-
Trends in Biochemical Sciences . Apr2003, Vol. 28 Issue 4, p215. 6p. - Publication Year :
- 2003
-
Abstract
- Although it has been known since the late 1970s that intron-containing and intronless versions of otherwise identical genes can exhibit dramatically different expression profiles, the underlying molecular mechanisms have only lately come to light. This review summarizes recent progress in our understanding of how introns and the act of their removal by the spliceosome can influence and enhance almost every step of mRNA metabolism. A rudimentary understanding of these effects can prove invaluable to researchers interested in optimizing transgene expression in eukaryotic systems. [Copyright &y& Elsevier]
- Subjects :
- *GENES
*INTRONS
*MESSENGER RNA
*TRANSGENE expression
Subjects
Details
- Language :
- English
- ISSN :
- 09680004
- Volume :
- 28
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Trends in Biochemical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 9544629
- Full Text :
- https://doi.org/10.1016/S0968-0004(03)00052-5