ChemInform Abstract: Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminum to β,γ-Unsaturated α-Ketoamides: Efficient Access to γ-Methyl-Substituted Carbonyl Compounds.

The asymmetric addition of AlMe3 to β,γ-unsaturated α-ketoamides affords 1,4-adducts with perfect 1,4-regioselectivity and good to excellent yields and enantioselectivity. [ABSTRACT FROM AUTHOR]