Appearance of de novo dysplastic spitzoid compound naevus in an adalimumab-treated psoriatic patient: Case report and review of the possible causal relationship with TNF-α blockers.

The article presents a case study of a 29-year-old white woman with a history of severe plaque psoriasis for 16 years. A pigmented macule was noted in the patient's right thigh, who received adalimumab, a tumour necrosis factor (TNF)-α blocker. The lesion was found to have atypical irregular borders and discoloration. A diagnosis of irritated dysplastic spitzoid compound naevus was made based on the presence of Kamino bodies and homogeneous upregulation of both p16 and p21 proteins.