Effects of a selective serotonin reuptake inhibitor escitalopram on the cutaneous silent period: A randomized controlled study in healthy volunteers.

Highlights: [•] The cutaneous silent period (CSP) is a spinal noxious inhibitory reflex. [•] Escitalopram shows a selective action in inhibiting serotonin reuptake. [•] Escitalopram increases CSP duration without affecting subjective pain sensation. [•] We provide evidence for monoaminergic system involvement in the generation of CSP. [ABSTRACT FROM AUTHOR]