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Association Between the FAS rs2234767G/A Polymorphism and Cancer Risk: A Systematic Review and Meta-Analysis.
- Source :
-
DNA & Cell Biology . May2014, Vol. 33 Issue 5, p320-327. 8p. - Publication Year :
- 2014
-
Abstract
- Abnormal regulation of apoptosis can lead to carcinogenesis. Single nucleotide polymorphisms in apoptotic genes have been associated with cancer risk, such as the FAS rs2234767G/A polymorphism, which alters transcription of the FAS promoter. Downregulation of FAS, with resultant cellular resistance to death signals, has been found in many cancers. However, the association between the FAS rs2234767G/A polymorphism and cancer risk is still controversial. Here, we performed a meta-analysis including 41 articles (44 case-control studies, 17,814 cases and 24,307 controls) identified from PubMed and Chinese language (CNKI and WanFang) databases related to cancer susceptibility and the FAS rs2234767G/A polymorphism. We used odds ratios (ORs) and 95% confidence intervals (CIs) to assess the strength of the associations. We found that the rs2234767 G-allele was a protective factor for cancer risk (GG vs. AA: OR=0.88, 95% CI=0.79-0.98; GG+GA vs. AA: OR=0.87, 95% CI=0.79-0.96). Similar associations were detected in the 'source of control', ethnicity, and cancer type subgroups. Further studies on a larger sample size and considering gene-environment interactions should be conducted to confirm the role of FAS polymorphisms, especially rs2234767G/A, in cancer risk. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10445498
- Volume :
- 33
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- DNA & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 95805143
- Full Text :
- https://doi.org/10.1089/dna.2013.2273