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Upregulation of mitochondrial protease HtrA2/Omi contributes to manganese-induced neuronal apoptosis in rat brain striatum.
- Source :
-
Neuroscience . May2014, Vol. 268, p169-179. 11p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Mn exposure induces HtrA2 upregulation in rat striatum. [•] Upregulated HtrA2 was correlated with XIAP reduction and marked neuronal apoptosis. [•] HtrA2 inhibitor UCF-101 attenuated Mn-triggered XIAP downregulation. [•] UCF-101 partially protects neuronal cells from Mn-induced apoptosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03064522
- Volume :
- 268
- Database :
- Academic Search Index
- Journal :
- Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 95828151
- Full Text :
- https://doi.org/10.1016/j.neuroscience.2014.03.003