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Systemic treatment of HER2-positive metastatic breast cancer: A systematic review.
- Source :
-
Asia Pacific Journal of Clinical Oncology . Jun2014 Supplement, Vol. 10, p1-14. 14p. - Publication Year :
- 2014
-
Abstract
- Aim We aimed to systematically review and summarize data from the available clinical trials that examined the treatment of HER2-positive metastatic breast cancer. Methods We reviewed phase 2 and 3 studies in which an anti- HER2 agent was used in one or both arms of the study. While formal meta-analysis was not possible for such a heterogeneous group of trials, resulting forest plots outline some generalizable findings. Results There is strong evidence that the addition of an anti- HER2 agent to standard chemo- or endocrine therapy improves clinically relevant measurable outcomes. There is also consistent evidence that initial treatment with trastuzumab alone (and subsequent use of a cytotoxic) is inferior to the initial combination of trastuzumab plus chemotherapy, and that either T-DM1 or dual anti- HER2 agents are superior to single anti- HER2 agent regimens. There is no strong evidence that the use of more than one cytotoxic agent together with an anti- HER2 agent confers any benefit over a single cytotoxic, anti- HER2 combination. Conclusion This review provides a strong evidence base for current clinical practice with a discussion of treatment in the Australian setting. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17437555
- Volume :
- 10
- Database :
- Academic Search Index
- Journal :
- Asia Pacific Journal of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 95876618
- Full Text :
- https://doi.org/10.1111/ajco.12206