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Cruciferous Vegetable Intake Is Inversely Correlated with Circulating Levels of Proinflammatory Markers in Women.
- Source :
-
Journal of the Academy of Nutrition & Dietetics . May2014, Vol. 114 Issue 5, p700-708. 9p. - Publication Year :
- 2014
-
Abstract
- Background Higher intakes of cruciferous vegetables or their constituents have been shown to lower inflammation in animal studies. However, evidence for this anti-inflammatory effect of cruciferous vegetable consumption in humans is scarce. Objective/Design In this cross-sectional analysis, we evaluated associations of vegetable intake with a panel of inflammatory and oxidative stress markers among 1,005 middle-aged Chinese women. Dietary intake of foods was assessed by a food frequency questionnaire. Results Multivariable-adjusted circulating concentrations of tumor necrosis factor-α (TNF-α), interlukin-1β (IL-1β), and IL-6 were lower among women with higher intakes of cruciferous vegetables. The differences in concentrations of inflammatory biomarkers between extreme quintiles of cruciferous vegetable intake were 12.66% for TNF-α (Ptrend=0.01), 18.18% for IL-1β (Ptrendd=0.02), and 24.68% for IL-β (Ptrend=0.02). A similar, but less apparent, inverse association was found for intakes of all vegetables combined but not for noncruciferous vegetables. Levels of the urinary oxidative stress markers F2-isoprostanes and their major metabolite, 2,3-dinor-5,6-dihydro-15-F2t-IsoP, were not associated with intakes of cruciferous vegetables or all vegetables combined. Conclusions This study suggests that the previously observed health benefits of cruciferous vegetable consumption may be partly associated with the anti-inflammatory effects of these vegetables. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SMOKING
*BIOMARKERS
*CHINESE people
*COMPARATIVE studies
*BRASSICACEAE
*DIET
*ALCOHOL drinking
*EMPLOYMENT
*EPIDEMIOLOGICAL research
*GENES
*HEALTH behavior
*INFLAMMATION
*INTERLEUKINS
*LONGITUDINAL method
*NUTRITIONAL assessment
*QUESTIONNAIRES
*RESEARCH funding
*STATISTICAL hypothesis testing
*TUMOR necrosis factors
*URINALYSIS
*STATISTICAL significance
*OXIDATIVE stress
*EDUCATIONAL attainment
*BODY mass index
*CONTINUING education units
*CROSS-sectional method
*DATA analysis software
*DESCRIPTIVE statistics
RESEARCH evaluation
Subjects
Details
- Language :
- English
- ISSN :
- 22122672
- Volume :
- 114
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of the Academy of Nutrition & Dietetics
- Publication Type :
- Academic Journal
- Accession number :
- 95901318
- Full Text :
- https://doi.org/10.1016/j.jand.2013.12.019