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Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus

Authors :
Lu, Zhijian
Raghavan, Subharekha
Bohn, Joann
Charest, Mark
Stahlhut, Mark W.
Rutkowski, Carrie A.
Simcoe, Amy L.
Olsen, David B.
Schleif, William A.
Carella, Anthony
Gabryelski, Lori
Jin, Lixia
Lin, Jiunn H.
Emini, Emilio
Chapman, Kevin
Tata, James R.
Source :
Bioorganic & Medicinal Chemistry Letters. May2003, Vol. 13 Issue 10, p1821. 4p.
Publication Year :
2003

Abstract

A series of highly potent HIV protease inhibitors have been designed and synthesized. These compounds are active against various clinical viral isolates as well as wild-type virus. The synthesis and biological activity of these HIV protease inhibitors are discussed. [Copyright &y& Elsevier]

Subjects

Subjects :
*PROTEASE inhibitors
*HIV
*VIROLOGY

Details

Language :
English
ISSN :
0960894X
Volume :
13
Issue :
10
Database :
Academic Search Index
Journal :
Bioorganic & Medicinal Chemistry Letters
Publication Type :
Academic Journal
Accession number :
9601679
Full Text :
https://doi.org/10.1016/S0960-894X(03)00262-2