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Effectiveness of a novel immunogenic nanoparticle platform for Toxoplasma peptide vaccine in HLA transgenic mice.

Authors :
El Bissati, Kamal
Zhou, Ying
Dasgupta, Debleena
Cobb, Drew
Dubey, Jitender P.
Burkhard, Peter
Lanar, David E.
McLeod, Rima
Source :
Vaccine. May2014, Vol. 32 Issue 26, p3243-3248. 6p.
Publication Year :
2014

Abstract

Highlights: [•] A novel self-assembling nanoparticle (SAPN) that contains the Toxoplasma gondii GRA720–28 peptide was successfully produced. [•] The SAPN elicits HLA-B*0702-restricted CD8+T cells responses in HLA-B*0702 mice. [•] Protective immune responses of SAPN against T. gondii type I and II strains. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0264410X
Volume :
32
Issue :
26
Database :
Academic Search Index
Journal :
Vaccine
Publication Type :
Academic Journal
Accession number :
96021797
Full Text :
https://doi.org/10.1016/j.vaccine.2014.03.092