Effects of dopamine D1 receptor blockade in the prelimbic prefrontal cortex or lateral dorsal striatum on frontostriatal function in Wistar and Spontaneously Hypertensive Rats.

Highlights: [•] Frontostriatal cognitive functions were disrupted in SHR compared to WIS. [•] SCH23390 infusions in prelimbic PFC worsened executive function in SHR. [•] SCH23390 infusions in prelimbic PFC impaired executive function in WIS. [•] SCH23390 infusions in lateral DST did not alter executive function in SHR or WIS. [•] SCH 23390 infusions in both sites produced relatively less habitual responding in WIS. [ABSTRACT FROM AUTHOR]