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Reduction of phosphodiesterase 3B gene expression in peroxisome proliferator-activated receptor γ (+/−) mice independent of adipocyte size
- Source :
-
FEBS Letters . May2003, Vol. 542 Issue 1-3, p65. 4p. - Publication Year :
- 2003
-
Abstract
- Phosphodiesterase 3B (PDE3B) gene expression is generally reduced in large adipocytes of obese, insulin-resistant mice. This reduced gene expression is restored by peroxisome proliferator-activated receptor (PPAR) γ ligands accompanied by a reduced fat cell size. To determine whether PDE3B gene expression is regulated by PPARγ itself, we analyzed lean PPARγ (+/−) mice with adipocyte size comparable to control PPARγ (+/+) mice. In adipocytes of PPARγ (+/−) mice, PDE3B mRNA and protein were both reduced to 63% of wild-type levels. Basal PDE activity tended to be decreased to 70% of wild-type levels, and, similarly, insulin-induced PDE activity was significantly decreased to 70%. Thus, PPARγ is required for PDE3B gene expression independent of adipocyte size. [Copyright &y& Elsevier]
- Subjects :
- *PHOSPHODIESTERASES
*GENE expression
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 542
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 9603385
- Full Text :
- https://doi.org/10.1016/S0014-5793(03)00339-9