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Parallel and antiparallel (G...GC)2 triple helix fragments in a crystal structure.

Authors :
Vlieghe, Dominique
Van Meervelt, Luc
Source :
Science. 9/20/1996, Vol. 273 Issue 5282, p1702. 4p. 9 Diagrams.
Publication Year :
1996

Abstract

Describes the x-ray crystal structure of the oligonucleotide d(GGCCAATTGG). Design of this structure to contain the d(G...GC)2 fragment, thus providing the basic repeat unit of a DNA triple helix; Significance of nucleic acid triplexes to genome analysis and antigene therapy.

Details

Language :
English
ISSN :
00368075
Volume :
273
Issue :
5282
Database :
Academic Search Index
Journal :
Science
Publication Type :
Academic Journal
Accession number :
9610107502
Full Text :
https://doi.org/10.1126/science.273.5282.1702