Palladium-catalyzed C3-selective mono-arylation of 4-hydroxycoumarin.

Authors :: Yakushiji, Fumika
Haramo, Masako
Miyadera, Yukari
Uchiyama, Chihiro
Takayama, Kentaro
Hayashi, Yoshio
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. May2014, Vol. 55 Issue 22, p3316-3318. 3p.
Publication Year :: 2014
Abstract: Abstract: 4-Hydroxycoumarin (1) is a useful synthon in synthetic organic chemistry and a basic skeleton of several bioactive compounds. The direct functionalization of 1 with novel catalytic system would provide an efficient meaning for construction of a chemical library. Here, we developed a new catalytic system using palladium(II) acetate for the C3 regioselective mono-arylation of 1. The 3-mono-arylated and the 3,4-disubstituted coumarins were synthesized to enable derivatization. This palladium-catalyzed direct arylation of 1 is effective for rapid diversification and chemical library construction. [Copyright &y& Elsevier]

Subjects :: *PALLADIUM catalysts
*ARYLATION
*COUMARINS
*ORGANIC chemistry
*BIOACTIVE compounds
*CHEMICAL libraries

Language :: English
ISSN :: 00404039
Volume :: 55
Issue :: 22
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 96174847
Full Text :: https://doi.org/10.1016/j.tetlet.2014.04.041