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Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance.
- Source :
-
Nature Genetics . Jun2014, Vol. 46 Issue 6, p558-566. 9p. 1 Chart, 6 Graphs. - Publication Year :
- 2014
-
Abstract
- The importance of microRNAs and long noncoding RNAs in the regulation of pluripotency has been documented; however, the noncoding components of stem cell gene networks remain largely unknown. Here we investigate the role of noncoding RNAs in the pluripotent state, with particular emphasis on nuclear and retrotransposon-derived transcripts. We have performed deep profiling of the nuclear and cytoplasmic transcriptomes of human and mouse stem cells, identifying a class of previously undetected stem cell-specific transcripts. We show that long terminal repeat (LTR)-derived transcripts contribute extensively to the complexity of the stem cell nuclear transcriptome. Some LTR-derived transcripts are associated with enhancer regions and are likely to be involved in the maintenance of pluripotency. [ABSTRACT FROM AUTHOR]
- Subjects :
- *STEM cells
*RETROTRANSPOSONS
*RNA
*NUCLEIC acids
*CYTOPLASM
Subjects
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 46
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Nature Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 96204258
- Full Text :
- https://doi.org/10.1038/ng.2965