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Basal NF-κB controls IL-7 responsiveness of quiescent naïve T cells.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 5/20/2014, Vol. 111 Issue 20, p7397-7402. 6p. - Publication Year :
- 2014
-
Abstract
- T cells are essential for immune defenses against pathogens, such that viability of naïve T cells before antigen encounter is critical to preserve a polyclonal repertoire and prevent immunodeficiencies. The viability of naive T cells before antigen recognition is ensured by IL-7, which drives expression of the prosurvival factor Bcl-2. Quiescent naive T cells have low basal activity of the transcription factor NF-κB, which was assumed to have no functional consequences. In contrast to this postulate, our data show that basal nuclear NF-κB activity plays an important role in the transcription of IL-7 receptor a-subunit (CD127), enabling responsiveness of naive T cells to the prosurvival effects of IL-7 and allowing T-cell persistence in vivo. Moreover, we show that this property of basal NF-κB activity is shared by mouse and human naïve T cells. Thus, NF-κB drives a distinct transcriptional program in T cells before antigen encounter by controlling susceptibility to IL-7. Our results reveal an evolutionarily conserved role of NF-κB in T cells before antigenic stimulation and identify a novel molecular pathway that controls T-cell homeostasis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*IMMUNODEFICIENCY
*ANTIGENS
*TRANSCRIPTION factors
*HOMEOSTASIS
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 111
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 96209787
- Full Text :
- https://doi.org/10.1073/pnas.1315398111