Back to Search
Start Over
The age and genomic integrity of neurons after cortical stroke in humans.
- Source :
-
Nature Neuroscience . Jun2014, Vol. 17 Issue 6, p801-803. 3p. - Publication Year :
- 2014
-
Abstract
- It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived 14C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NUCLEIC acids
*GENES
*NEURONS
*GENOMES
*CEREBRAL cortex
Subjects
Details
- Language :
- English
- ISSN :
- 10976256
- Volume :
- 17
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Nature Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 96221335
- Full Text :
- https://doi.org/10.1038/nn.3706